The National Institute for Occupational Safety and Health (NIOSH) requests assistance in controlling exposures of workers to nitrous oxide (N2O) during the administration of anesthetic gas in medical, dental, and veterinary operatories.
Epidemiologic studies have suggested an association between exposure to mixed anesthetic gases and impaired fertility. We investigated the effects of occupational exposure to nitrous oxide on the fertility of female dental assistants.
This study provides direct evidence that occupational exposure to nitrous oxide may cause depression of vitamin B12 activity resulting in measurable changes in bone marrow secondary to impaired synthesis of deoxyribonucleic acid.
Normal serum concentrations of methionine, leucine, isoleucine and valine have been found in 10 anaesthetists using nitrous oxide under their regular working conditions without scavenging of patients’ exhaled gas.
- CDC – NIOSH Publications and Products – Controlling Exposures to Nitrous Oxide During Anesthetic Administration (94-100), May 2020
- The New England Journal of Medicine, October 1, 1992
- British Medical Journal, Volume 291, August 31, 1985
- British Journal of Anaesthesia, 1982, 54, 593